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I suggest inhibiting the original sentence off point step 3

We surmise that results obtained from the experiments described in this section cannot serve to understand the role of I_NaL in arrhythmogenesis.

step one. Van Driessche W, Lindemann B: Concentration reliance out-of currents because of single sodium-choosy pores within the frog skin. Nature. 1979; 282 (5738): 519-520 PubMed Abstract | Journalist Full Text

This means the new good findings submit from this manuscript is perhaps not justified and that i do not accept the newest manuscript contained in this setting

The newest article authors has actually clarified many of the inquiries We increased from inside the my prior feedback. Sadly, most of the significant problems haven’t been handled through this revision. When i produced in my personal earlier comment, We deem they unlikely that all men and women issues might be repaired simply because of the several extra sentences. Rather you can still find certain important questions with the fresh framework and you may, extremely significantly, towards study.

This means the newest good findings put forward through this manuscript was perhaps not warranted and i also usually do not accept the newest manuscript in this setting

The writers provides clarified several of the inquiries I increased when you look at the my prior opinion. Sadly, the significant dilemmas have not been addressed from this revision. When i manufactured in my earlier in the day opinion, We consider it unlikely that every men and women activities shall be fixed only by a number of additional sentences. Rather you may still find certain simple questions towards the experimental construction and you will, most vitally, for the investigation.

• Top issue is that when I observed the newest malfunction out of the methods in the last version it was you are able to to help you decode, that have almost best reliability, any arbitrary stimulus labels I chose. Find to possess samples of that it reanalysis. Regardless of whether we pretend your genuine stimulus looked on an afterwards day or is actually constantly switching ranging from signal and silence, the decoding is always near to best. This is an indication that decoding doesn’t have anything to do towards actual stimuli heard because of the Transmitter but is opportunistically exploiting different have regarding the study. The fresh manage data the fresh article authors did, reversing the newest stimuli labels, cannot target this matter since it suffers from equivalent condition. Basically, exactly what the classifier is allegedly playing with it’s time that has passed given that tape come.
• The cause of this is certainly presumably that article writers utilized non-separate data for education and you will research. Just in case I am aware accurately (pick part 3), haphazard sampling 1 / 2 of data products out of an enthusiastic EEG shadow are not separate analysis. Repeated the study five times the latest manage study the newest people did isnt an adequate treatment for target this question. At random wanting samples of an occasion collection which has slow alter (including the slow revolution hobby one to allegedly dominates such recordings lower than these scenarios) will invariably include solid temporal correlations. Select TemporalCorrelations.jpg in for 2D thickness histograms and you will a correlation matrix indicating this.
• While the modified steps area will bring greater detail today, it continues to be confused about just what studies were utilized. Conventional class data report what study provides (usual columns on the data matrix) and you can just what observations (usual rows) were used. Anything could be a feature however, usually this can be the fresh additional EEG avenues or fMRI voxels etcetera. Observations are usually day affairs. Here I assume the fresh people switched the newest intense examples towards the a some other room having fun with dominant component research. This isn’t said in the event the dimensionality are quicker utilising the eigenvalues. Regardless, I suppose the info trials (compiled on 128 Hz) was indeed after that put since the findings as well as online assignment writing the EEG channels turned by PCA were utilized once the has. The new stimuli labels was basically assigned since the On or Off for each attempt. A collection of 50% off samples (and you will names) ended up being chose randomly to own degree, while the others was utilized to have evaluation. Is this proper?